SAN DIEGO — Researchers in California have found that U.S. men who have sex with men and use methamphetamine had greater T-cell activation and proliferation than non-users, even though they had an undetectable viral load.
The study, conducted by researchers at the University of California at San Diego, studied 50 men and produced evidence that meth users may have a deeper HIV DNA reservoir than non-users.
Users who are HIV-positive have a higher risk of cognitive impairment and faster progression to AIDS, researchers said.
But the reasons for these associations remain unclear. Worse antiretroviral adherence or meth-related risk behaviors could explain worse health outcomes in meth users, or some physiologic mechanism could explain these health deficits, researchers said.