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Working to end HIV

Foundation plans D.C. fundraiser to boost vaccine effort

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Zachary Barnett will be in town next week for an HIV benefit at Mitchell Gold + Bob Williams. (Photo courtesy Mitchell Gold + Bob Williams)

Abzyme Research Foundation is partnering with Mitchell Gold + Bob Williams (1526 14th St., N.W.) and Cork Wine Bar for “Taste for Change,” a wine tasting and fundraising event to support an effort to end HIV/AIDS, on Tuesday at 7 p.m.

“We’re really excited to bring the presentation to D.C.,” says Zachary Barnett, executive director and found of ARF. “There’s a lot of energy … with the non-profit world and the government sector.”

ARF is a non-profit organization hoping to end HIV/AIDS by researching abzyme technology to produce the world’s first effective therapeutic HIV vaccine. Barnett compares this technology to the recent advancements and FDA approval for a shingles vaccine.

“Once you’re infected with chicken pox, you have that virus in your cells forever, but what the vaccine does … it’s effectively suppressing new outbreaks of infection,” Barnett says. “What we’re talking about is effectively the same. What if we could create a vaccine after you’ve already been infected, that would suppress the virus in your system.”

Barnett, infected by a partner in 2008, was recently named one of The Advocate’s “40 Under 40.” His nomination came at a time when he was considering being more public about his status. A friend had recently called him out on it.

“The chain of events was so weird,” Barnett says. “I kind of made the decision … and then The Advocate called me a couple days later … It was a really cool and serendipitous chain of events. I was happy to be given the opportunity to do it.”

Barnett started as a marketing and events consultant when he moved to New York City in 2006.

After finding out he was infected, Barnett brought his skills and passion to the world of HIV research advocacy.

“Fundraising and non-profit work, a lot of it is storytelling and communication,” Barnett says. “Creating event series and forums to talk to people and engage in communication is key to success, especially in the beginning.”

What started as a moment of personal crisis became a reason for Barnett to do more research on HIV/AIDS and its treatments, including the state of HIV/AIDS internationally. This research brought led him to a 2008 video by CBS, “Possible HIV Cure” with Dr. Sudhir Paul and his science team at University of Texas.

Barnett reached out to Paul and with the help of Marie LaFrance from Interview Magazine, threw a gala for the researcher and launched a PSA featuring Wilson Cruz, Justin Bond and Lady Bunny to engage supporters.

“I’m incredibly inspired by the doctors we’re working with,” Barnett says. “I think they’ve developed such an interesting, creative approach to battling the disease.”

Paul was first awarded a grant from the National Institute of Health in 1990. He’s published a paper identifying the CD4 binding site on the HIV outer coat as the “Achilles heel” of HIV. He has found that the human immune system has the innate ability to produce abzymes.

An abzyme, or an antibody-enzyme, is capable of starting the destruction of targeted molecules. A single molecule of an abzyme can trigger the destruction of thousands of target molecules and abzymes produced in animals have successfully blocked infection of human cells by genetically diverse HIV strains.

“This is completely hypothetical, and maybe getting ahead of ourselves, but … the abzyme technology has numerous applications,” Barnett says. “If this turns out to be a really dynamic technology that has the ability to make an impact on HIV, I’m excited to see where else we can take it.”

ARF’s goal is to raise $1.5 million for a FDA Phase I human trial, ideally in an HIV-positive population, to prove the E-Vaccine is safe and will induce antibodies that neutralize HIV in laboratory tests. According to its website, ARF, which has already covered its operation funding for the year, has raised $50,000 so far.

“We’re looking at a post-infection vaccine … exploring alternatives for daily anti-retroviral treatment. Can we develop a vaccine that will produce a robust antibody response in populations infected by HIV?,” Barnett says of the endeavor.

The Phase I human trial is the third milestone required to obtain FDA approval, according to an introduction brochure by ARF. The last being phase two and three efficacy trials to prove that the E-Vaccine will protect individuals who are at risk of being infected and prove control of virus infection occurs in infected individuals receiving the vaccine.

The organization has already secured a donor who will match the first $200,000 donated.

For more information on the organization or to donate, visit endhiv.com. The organization can also be followed at twitter.com/endhiv. To learn more about the fundraising event and to RSVP, email [email protected].

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Arts & Entertainment

The very few queer highlights of the Oscars

Streisand’s live performance, a shocking tie, and more

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(Photo courtesy of AMAS)

LOS ANGELES — While Sunday’s Academy Awards saw the expected winners “One Battle After Another” and “Sinners” nab a collective 10 Oscars throughout the evening, dominating most of the major categories, there were a few moments for queer film fans to celebrate.

During the ceremony’s prolonged and emotional In Memoriam segment, which paid tribute to Robert Redford, Rob Reiner, and Catherine O’Hara, queer icon Barbra Streisand went on stage and gave a rare live performance of “The Way We Were” as a tribute to Redford, who died last September at the age of 83. Before singing, Streisand said, “Now, Bob had real backbone on and off the screen. He spoke up to defend freedom of the press, protect the environment, and encouraged new voices at his Sundance Institute — some of whom are up for Oscars tonight, which is so great. He was thoughtful and bold.”

Both “I Lied to You” from “Sinners” and “Golden” from “KPop Demon Hunters” were performed live; Alabama Shakes front woman Brittany Howard performed during the evening’s powerful rendition of “Sinners’” “pierce the veil” scene. “Golden” ended up winning the Best Original Song award.

One of the most shocking moments of the night arrived early on when Kumail Nanjiani presented the Best Live Action short category, which was a tie between “The Singers” and “Two People Exchanging Saliva” — only the seventh tie in Oscars history (one of which involved Streisand’s 1969 win for “Funny Girl”). The latter short, which is currently streaming on The New Yorker, is described as “a dystopian version of Paris where kissing is forbidden and purchases are made through small acts of violence” and follows the unexpected connection between two women.

When accepting the award, “Two People Exchanging Saliva” director and producer Natalie Musteata said: “Thank you to the Academy for supporting a film that is weird, and that is queer, and that is made by a majority of women!”

“One Battle After Another’s” editor, Andy Jurgensen (who collaborated with Paul Thomas Anderson on “Licorice Pizza” and “Phantom Thread”), kissed his husband before going on stage to accept his award for film editing. He said, “To my partner, Bill, who brings so much joy to my life every day.”

Overall, the 2026 award season did not feature many queer films or actors in the lineup, and that was reflected in both the Oscar nominees and eventual winners. Smaller award shows like the Gotham Awards and the Film Independent Spirit Awards provided opportunities for indies like “Sorry, Baby,” “Twinless,” and “Lurker” to get proper recognition. “One Battle After Another” won Best Picture and Best Director for Paul Thomas Anderson; “Sinners” star Michael B. Jordan won Best Actor; and “Hamnet’s” Jessie Buckley won Best Actress.

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Photos

PHOTOS: Awesome Con

George Takei speaks on the main stage

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George Takei was among the featured guests at Awesome Con on March 14. (Washington Blade photos by Michael Key)

The annual fantasy, comics and science fiction convention Awesome Con was held at the Walter E. Washington Convention Center on March 13-15. Featured guests included openly gay actor, author and activist, George Takei. The convention included LGBTQ panels and a “Pride Alley” with LGBTQ-specific booths in the exhibit hall.

(Washington Blade photos by Michael Key)

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Theater

A season of renewal for D.C. theater

‘Streetcar,’ ‘Hamnet,’ ‘Hamlet,’ and many more

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Ismenia Mendes plays Ana in ‘Jonah’ at Studio Theatre. (Photo by Krystena Patton)

Ideally, spring is our season of renewal – personal, emotional, and social. Lucky for those in the DMV, there’s a lot of exhilarating new theater to help make it happen. 

At Arena Stage, there’s still time to catch the world premiere production of “Chez Joey” (extended through March 22). Set around the 1940s Chicago jazz scene, this smart reboot of the Broadway classic “Pal Joey” effervesces with music by Rodgers and Hart and a terrific cast brimming with big talent (including Myles Frost, Awa Sal Secka, and out comedic actor Kevin Cahoon). 

Also at Arena, is “Inherit the Wind” (through April 5), the extraordinarily timely work based on the real-life Scopes “Monkey” Trial. It’s a courtroom drama that pits two towering legal minds against each other in a small-town battle over science, religion, and the right to think. The large, talented cast includes Billy Eugene Jones, Dakin Matthews, and out actors Holly Twyford and Alyssa Keegan.  Arenastage.org 

La Pluma Theatre, a queer Latin company housed in Dupont Underground, presents “The Ladybird of Saint John” (April 6-12), a powerful story about two sisters navigating immigration, separation, and the fragile bonds of family. @laplumatheatre – Instagram 

Great gay playwright Tennessee Williams’ “A Streetcar Named Desire” (April 20–May 4) is also coming to the Dupont Underground space. Directed by out actor/director Nick Westrate, the touring production of Williams’s classic work set in New Orlean’s steamy Vieux Carré is performed with neither set nor props. It focuses on the words. Lucy Owen and Brad Koed star as fragile Blanche Dubois and her brutal brother-in-law Stanley. Dupontunderground.org

Folger Theatre is serving up one of the Bard’s best comedies, “As You Like It” (through April 12). Staged by out director Timothy Douglas, Folger’s production “offers a love note to D.C., imbuing the forest of Arden with the familiar vibes, culture, and characters that mark the District as a singular, resilient, and redemptive place of belonging.” Folger.edu 

As part of the country’s semi-quincentennial celebrations, Ford’s Theatre presents “1776” (through May 16), a Tony Award-winning musical about the Second Continental Congress’s struggle to adopt the Declaration of Independence in Philadelphia. Directed by Luis Salgado, the show features a large cast including queer talent like Tom Story, Jake Loewenthal, Jimmy Mavrikes, and Wood Van Meter. Fords.org 

In Falls Church, Creative Cauldron presents “Twelve Dancing Princesses” (through March 29), a Learning Theater Production targeting both kids and adults. Adapted from a Brothers Grimm tale, the eerie story features Spanish language elements and original music by husbands Matt Conner and Stephen Gregory Smith. Creativecauldron.org 

The National Theatre presents “Disney’s Beauty and the Beast” (March 18–April 5). This musical “tale as old as time” is a love story involving Belle, a cursed beast, and the arrogant and famously spurned Gaston played out actor Stephen Mark Lukas, a beauty in his own right. Broadwayatthenational.com 

At Mosaic Theater Company, Michael Bahsil-Cook plays the titular activist/congressman in Psalmayene 24’s “Young John Lewis: Prodigy of Protest.” (March 26–May 3). Staged by Mosaic’s out artistic director Reginald L. Douglas, focuses on Lewis’s formative years of ages 18-28, revealing the budding humanity and heart of this mighty historic figure. Talented out actor Vaughn Ryan Midder plays legendary civil rights activist Medgar Evers and other parts. Mosaictheater.org 

At Olney Theatre Center, it’s the anticipated area premiere of “Appropriate” (March 18–April 19). Penned by Tony Award-winning out playwright Branden Jacobs-Jenkins, the darkly comic work follows a dysfunctional white family that gathers on a plantation home to liquidate their late father’s estate where they uncover a dark history of racism.

Excellent area actors Kimberly Gilbert and Cody Nickell play siblings battling over possessions as well as their father’s shady legacy. Performed in Olney’s black box Mulitz-Gudelsky Theatre Lab, the company promises a unique staging of this important American play.  Jason Loewith directs. 

Also at Olney Theatre, celebrity chef and longtime queer ally Carla Hall debuts her one-woman show, “Carla Hall — Please Underestimate Me” (June 3–July 12). Olneytheatre.org 

British imports are striding the boards at Shakespeare Theatre Company this spring. The first is “Hamnet” (March 17–April 12), the U.S. premiere of the Royal Shakespeare Company’s 2023 stage adaptation of Maggie O’Farrell’s best-selling novel about the life of Shakespeare’s wife, Agnes, and the death of their son.

And then it’s “Eddie Izzard in the Tragedy of Hamlet” (March 27–April 11), a one-woman show in which the British comedian takes on 23 characters in a unique re-telling of the renowned work. Shakespearetheatre.org 

Woolly Mammoth Theatre presents “Travesty” (March 24–April 12). Created and performed by gender fluid drag performer Sasha Velour, the one-person show is part performance art, part history, and part call to action.

Also at Woolly, out actor Justin Weaks stars in his solo piece “A Fine Madness” (June 2–21), in which the Helen Hayes Award-winning actor shares his personal experience as a Black gay man receiving a positive HIV diagnosis. Woollymammoth.net

Spring at Studio Theatre is Rachel Bonds’ “Jonah” (through April 19), an exploration of a woman’s life through relationships with three men. Directed by Taylor Reynolds, the young five-person cast includes Rohan Maletira in the title role and Ismena Mendes as Ana. Mendes is an accomplished stage and screen actor whose described as bisexual/queer in her IMBD bio. Studiotheatre.org 

In Arlington, Signature Theatre’s out artistic director Matthew Gardiner stages “Pippin” (May 12–July 26), Stephen Schwartz’s musical about a young prince searching for a terrific life guided by a theatrical troupe. The original 1972 production featured stars like Ben Vereen and Irene Ryan (best known as TV’s Granny Clampett). Signature’s production’s big names have yet to be shared. Sigtheatre.org 

Exciting stuff ahead. 

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