Republican U.S. Sen. Lindsey Graham (R-S.C.) has died, and what he has left behind is a power vacuum for his U.S. Senate seat — and within the Republican Party.

The South Carolina senator had been a major part of Republican politics up until his Saturday death at his home in Washington, reportedly of an aortic dissection related to arteriosclerotic cardiovascular disease.

Graham has been a fixture in government at both the state and federal level. He began his political career in the South Carolina House of Representatives in 1992, representing the Palmetto State’s 2nd District before eventually moving to the federal government.

He moved up to Capitol Hill after his 1994 run for the U.S. House of Representatives. In 2003 he stepped across the rotunda to the Senate in 2003 following the retirement of longtime U.S. Sen. Strom Thurmond.

He consistently opposed LGBTQ rights while alive.

He voted against the 2022 Respect for Marriage Act, saying the decision should be left up to state governments, and the 2013 Employment Non-Discrimination Act, and opposed the repeal of Don’t Ask, Don’t Tell.

With Graham’s sudden passing, the Republican Party is scrambling to find a replacement who can advance both its goals and those of the president as Republicans’ supermajority in the federal government begins to shrink.

Among those reportedly in the running is Treasury Secretary Scott Bessent, the highest-ranking openly LGBTQ federal official in American history and fifth in the presidential line of succession.

Bessent, a South Carolina native, was formerly a supporter of the Democratic Party and donated to several Democratic presidential candidates before switching parties in 2017 following Trump’s election in 2016. He later donated $1 million to Trump’s 2017 presidential inaugural committee.

On Sunday, Bessent was also fielding calls from people asking him to run, according to a person familiar with the communications. A person close to Bessent told Politico that he is not interested in the seat, saying he is happy in his role as Treasury secretary, a position he has long wanted.

The Washington Blade reached out to the Treasury Department for comment, but did not receive a response by publication time.

One of the most anticipated and widely discussed names for the vacant Senate seat is Lt. Gov. Pamela Evette.

Evette is a staunch supporter of President Donald Trump and has gone as far as criticizing Republicans for not supporting the conspiracy theory that the 2020 presidential election was stolen. Trump also endorsed her gubernatorial campaign, though she ultimately lost to her now-boss, Gov. Henry McMaster.

McMaster has a long history of opposing LGBTQ rights.

During an October 2022 gubernatorial debate, McMaster said that if the U.S. Supreme Court overturned Obergefell v. Hodges, he would enforce South Carolina’s preexisting law banning same-sex marriage. In 2022, he also signed legislation requiring student athletes from elementary school through college to compete on teams corresponding to the sex listed on their birth certificates.

Other names reportedly being considered include U.S. Rep. Nancy Mace (R-S.C.), who has had a contentious relationship with LGBTQ issues during her time in Congress. She began as a supporter of LGBTQ rights, becoming one of the few Republicans to publicly support the Respect for Marriage Act, before making a complete about-face as transgender issues became a central part of the Republican Party’s political strategy.

As part of that strategy, Mace introduced a resolution to ban trans women from using female restrooms in the U.S. Capitol, a move she acknowledged was in direct response to the election of U.S. Rep. Sarah McBride (D-Del.), the first out trans person elected to Congress.

In a November 2024 post on X, Mace wrote: “We support gay marriage, and voted for the Respect for Marriage Act twice. However, if you think protecting women is discrimination, you are the problem. We don’t care if you’re trans, if you have balls we don’t want you in the women’s bathroom.”

Two other names being floated are U.S. Rep. Russell Fry, who represents South Carolina’s 7th Congressional District, and U.S. Rep. Ralph Norman, who represents the state’s 5th Congressional District.

Trump recommended Graham’s sister, Darline Graham, should serve as the state’s temporary senator in a post on Truth Social on Monday.

“This would be a fabulous tribute to Lindsey, who loved her dearly!” Trump wrote on his social network.

The scramble comes as Republicans hold increasingly narrow majorities over Democrats in both the Senate and House, potentially complicating efforts to advance Trump’s agenda. That agenda includes continuing the war in Iran, securing Todd Blanche’s confirmation as attorney general, and adding $350 billion in defense spending to the SAVE America Act — a controversial proposal deemed a “Jim Crow 2.0” among voting rights advocates.

McMaster is expected to announce Graham’s interim replacement on Monday at 4 p.m.